To inform IVF patients of the risks and limitations of PGS / PGT-A (genetic testing of embryos)
03/08/2023
Is IVF Genetic Testing (PGT-A) Useful For Older Egg Freezing Patients? – Dr Alexis Heng Boon Chin - CodeBlue It may be highly cost-inefficient to utilise the PGT-A procedure for older egg freezing patients.
03/08/2023
Risky and unnecessary embryo genetic testing (PGT-A) in Malaysia is driven by culture
Risky and unnecessary embryo genetic testing (PGT-A) in Malaysia is driven by culture - BioEdge Currently in Malaysia, many fertility clinics strongly encourage and even push their patients to do highly expensive preimplantation genetic testing of their IVF embryos, technically referred to as PGT-A or PGS. It is widely claimed that this technique not only prevent birth defects in older women s...
03/08/2023
Widespread Embryo Genetic Testing (PGT-A) In Malaysia May Not Benefit IVF Success Rates – Dr Alexis Heng Boon Chin Patients should think twice before choosing to add on the PGT-A technique to their IVF cycle.
03/08/2023
Malaysia needs stricter regulation of the genetic testing of embryos Photo: EVGENIY SALOV/Dreamstime/Tribune News Service DOWN syndrome is the most common genetic abnormality in newborns, and it is caused by the presence of an additional chromosome 21. As World Down Syndrome day approaches on March 21, we are reminded of the sobering statistic that around 90% of Down...
12/07/2022
Why Assessing Genetic Normality Of IVF Embryos By AI Is A Better Option
Why Assessing Genetic Normality Of IVF Embryos By AI Is A Better Option – Dr Alexis Heng Boon Chin - CodeBlue It might be preferable for older women undergoing IVF to screen their embryos for genetic abnormalities, before transferring them into their wombs.
19/11/2021
Cost-effectiveness of doing genetic testing of IVF embryos ( PGS / PGT-A ) to prevent Down syndrome and other genetic abnormalities in older mothers
Cost-effectiveness of doing genetic testing of IVF embryos ( PGS / PGT-A ) to prevent Down syndrome and other genetic abnormalities in older mothers - The New Savvy Currently, there is an increasing trend of late motherhood in Singapore and many other countries throughout the world, as rising numbers of better-educated women choose to postpone marriage and childbearing in pursuit of career development. Nevertheless, there are heightened risks of conceiving a ba...
14/10/2021
IVF genetic testing to prevent birth defects in older women https://www.biospectrumasia.com/opinion/54/19177/ivf-genetic-testing-to-prevent-birth-defects-in-older-women.html?fbclid=IwAR13Ka9CszB9YHWFMZMav-W_EJJcTpoY-CrwTTDcmBy7upyNmpbsBRvXBKU
"IVF genetic testing to prevent birth defects in older women" In conversation with Dr. Alexis Heng Boon Chin, Associate Professor, Peking University, China
14/10/2021
Genetic Testing Of IVF Embryos Overseas: What Singaporean Patients Should Know
Genetic Testing Of IVF Embryos Overseas: What You Should Know | theAsianparent Many Singaporean patients who travel abroad for fertility treatment, often end up choosing to do genetic testing of their IVF embryos.
10/03/2021
High attrition rate of 72% for PGS / PGT-A pilot trial in Singapore - as announced by Ministry of Health (MOH) - Why?
https://singaporemotherhood.com/forum/threads/pgs-pgt-a-in-singapore-high-attrition-rate-of-72-reported-by-ministry-of-health-moh-why.263844/
PGS / PGT-A in Singapore - High attrition rate of 72% reported by Ministry of Health (MOH) - Why? The Ministry of Health in Singapore has reported that the pilot trial of PGS / PGT-A in Singapore suffers from a high attrition rate of 72%. The question is Why? Please see: https://www.channelnewsasia.com/news/singapore/rahayu-mahzam-on-pre-implantation-genetic-screening-14313308 MP Rahayu...
20/02/2021
Abnormal embryos diagnosed by PGS / PGT-A can give rise to normal healthy births. PGS maybe unnecessary and a waste of money!
Please take note of the controversy surrounding PGS with regards to Mosaic embryos, which have a mixture of normal (euploid) and abnormal (aneuploid) cells. These are often tested to be genetically abnormal by PGS, but in fact can give rise to normal healthy births.
As seen in the attached diagram of a blastocyst-stage human embryo, the ICM gives rise to the embryo, while the TE gives rise to the placenta and yolk sac. Testing a few cells from the TE only gives you a probability about what's going on in the ICM. An embryo with abnormal (aneuploid) TE but normal ICM most likely will still make a healthy baby.
Hence, by discarding such mosaic embryos that are tested abnormal during PGS, one would lower the cumulative chances of IVF success.
20/02/2021
PGS (PGT-A) is prone to misdiagnosis due to mosaic embryos. Discarding of mosaic embryos that are tested to be abnormal by PGS (PGT-A), but which could otherwise give rise to normal healthy births, lowers the chances of IVF success.
30/01/2021
New scientific evidence dispute the beneficial effects of PGS / PGT-A in IVF treatment
New scientific evidence dispute the beneficial effects of PGS / PGT-A in IVF treatment Many fertility clinic websites claim that PGS can improve IVF success for older women and patients with multiple IVF failures or recurrent miscarriages. However, there has recently been increasing contradictory information from different sources, which dispute the beneficial claims of PGS in IVF...