Digital Politics Podcast

Alon Ben-Noon, CEO and board member of NeuroSense Therapeutics, is taking a unique approach to treating neurodegenerative diseases by targeting core pathologies and combining molecules to address various mechanisms. NeuroSense has seen positive clinical trial results for ALS using their lead compound PrimeC, which showed a reduction in disease progression. Research indicates the potential for this approach to be applied to other neurodegenerative diseases like Alzheimer's and Parkinson's.

Alon explains, "The main challenge is to find a therapeutic asset for a complex disease, which is still not understood well enough to date. ALS, also Alzheimer's, and I think that Parkinson's is among them as well. All of those neurodegenerative diseases are very complex and involve many mechanisms that go wrong. We try to tackle them with the therapeutic agents while we are not certain with each patient what exactly goes on. This is a huge challenge, so we need to be creative and find ways how we may be able to provide benefits to the majority of the patients, and I should be more distinct to say a benefit to some extent."

"In order to maximize the success with our therapy, we figured out that we need to target more than just one single mechanism and we need to tackle as much as we can or as many as we can. And looking at the more pertinent targets in our view and our understanding, we combine two molecules that target several mechanisms in a synergistic manner. We found molecules that can target these pathological pathways that were identified from the start. Also, it was important for us to see that they can work synergistically together on these targets."


NeuroSense-TX.com

Empowered Patient Podcast: Combination Drug Targets Core Pathologies of ALS Parkinson’s and Alzheimer’s with Alon Ben-Noon NeuroSense Therapeutics TRANSCRIPT Alon Ben-Noon, CEO and board member of NeuroSense Therapeutics, is taking a unique approach to treating neurodegenerative diseases by targeting core pathologies and combining molecules to address various mechanisms. NeuroSense has seen positive clinical trial results for ALS using their lead compoun...

Alon Ben-Noon, CEO and board member of NeuroSense Therapeutics, is taking a unique approach to treating neurodegenerative diseases by targeting core pathologies and combining molecules to address various mechanisms. NeuroSense has seen positive clinical trial results for ALS using their lead compound PrimeC, which showed a reduction in disease progression. Research indicates the potential for this approach to be applied to other neurodegenerative diseases like Alzheimer's and Parkinson's.

Alon explains, "The main challenge is to find a therapeutic asset for a complex disease, which is still not understood well enough to date. ALS, also Alzheimer's, and I think that Parkinson's is among them as well. All of those neurodegenerative diseases are very complex and involve many mechanisms that go wrong. We try to tackle them with the therapeutic agents while we are not certain with each patient what exactly goes on. This is a huge challenge, so we need to be creative and find ways how we may be able to provide benefits to the majority of the patients, and I should be more distinct to say a benefit to some extent."

"In order to maximize the success with our therapy, we figured out that we need to target more than just one single mechanism and we need to tackle as much as we can or as many as we can. And looking at the more pertinent targets in our view and our understanding, we combine two molecules that target several mechanisms in a synergistic manner. We found molecules that can target these pathological pathways that were identified from the start. Also, it was important for us to see that they can work synergistically together on these targets."


NeuroSense-TX.com

Empowered Patient Podcast: Combination Drug Targets Core Pathologies of ALS Parkinson’s and Alzheimer’s with Alon Ben-Noon NeuroSense Therapeutics Alon Ben-Noon, CEO and board member of NeuroSense Therapeutics, is taking a unique approach to treating neurodegenerative diseases by targeting core pathologies and combining molecules to address various mechanisms. NeuroSense has seen positive clinical trial results for ALS using their lead compoun...

Dr. Kathy Reeves, President and CEO of the Arnold P. Gold Foundation, works with medical schools to promote humanistic care and is responsible for the White Coat ceremony for medical students to emphasize the need for human connection in healthcare. The Foundation is also responsible for the Thank a Resident Day and the Gold Foundation Honor Society, which recognize those doctors who meet the high standards of their peers. The development of Gold Human-Centered Spaces is a scalable solution to create healthcare environments that foster humanistic interactions. The goal is to make humanism a healthcare priority and to implement practical solutions.

Kathy explains, "With that, Arnold and Sandra knew there had to be a foundation dedicated to making sure the human connection remained central in healthcare. And that's what the Gold Foundation has done and continues to do. We are the group that is responsible for the White Coat ceremony when people enter medical school to make sure medical students are aware that it's all about the person in front of them. There are a number of other programs that we do with medical schools, and we're attached to over 90% of the medical schools across the country. We work directly with these schools to help keep healthcare human."

"There is an abundance of research out there that will show you when a patient feels well cared for, they're healthier. When the interaction goes well, the healthcare professional is healthier. Those two things alone lead to lower healthcare costs, less no-show rates, less health professional turnover. So it is in some ways the epitome of value-based care, if we really value people, it's going to save money. It's going to make the society healthier."


gold-foundation.org

Empowered Patient Podcast: Impact of Humanistic Care on Healthcare Providers and Patient Outcomes with Dr. Kathy Reeves Arnold P. Gold Foundation TRANSCRIPT Dr. Kathy Reeves, President and CEO of the Arnold P. Gold Foundation, works with medical schools to promote humanistic care and is responsible for the White Coat ceremony for medical students to emphasize the need for human connection in healthcare.  The Foundation is also responsible for the T...

Dr. Kathy Reeves, President and CEO of the Arnold P. Gold Foundation, works with medical schools to promote humanistic care and is responsible for the White Coat ceremony for medical students to emphasize the need for human connection in healthcare. The Foundation is also responsible for the Thank a Resident Day and the Gold Foundation Honor Society, which recognize those doctors who meet the high standards of their peers. The development of Gold Human-Centered Spaces is a scalable solution to create healthcare environments that foster humanistic interactions. The goal is to make humanism a healthcare priority and to implement practical solutions.

Kathy explains, "With that, Arnold and Sandra knew there had to be a foundation dedicated to making sure the human connection remained central in healthcare. And that's what the Gold Foundation has done and continues to do. We are the group that is responsible for the White Coat ceremony when people enter medical school to make sure medical students are aware that it's all about the person in front of them. There are a number of other programs that we do with medical schools, and we're attached to over 90% of the medical schools across the country. We work directly with these schools to help keep healthcare human."

"There is an abundance of research out there that will show you when a patient feels well cared for, they're healthier. When the interaction goes well, the healthcare professional is healthier. Those two things alone lead to lower healthcare costs, less no-show rates, less health professional turnover. So it is in some ways the epitome of value-based care, if we really value people, it's going to save money. It's going to make the society healthier."


gold-foundation.org

Empowered Patient Podcast: Impact of Humanistic Care on Healthcare Providers and Patient Outcomes with Dr. Kathy Reeves Arnold P. Gold Foundation Dr. Kathy Reeves, President and CEO of the Arnold P. Gold Foundation, works with medical schools to promote humanistic care and is responsible for the White Coat ceremony for medical students to emphasize the need for human connection in healthcare.  The Foundation is also responsible for the T...

Bryan Miller, President of Neptune Ops, discusses how browser companies are changing their policies regarding the use of cookies to locate specific individuals and the need for new campaign strategies to find and persuade voters online. In the post-cookie world, political consultants must consider new identifiers based on other data, surgical contextual targeting, and geo-fencing.

We talk about:
* What replaces cookies to identify and target specific voters or groups
* Voting propensity, voter turnout, and when people decide how they are going to vote
* Finding persuadable voters
* How voters are consuming media
* Use of humor in political and advocacy ads
* Reaching diverse and younger voters
* Election Month not Election Day


NeptuneOps.com

Digital Politics with Karen Jagoda: Targeting Voters in a Post-Cookie World with Bryan Miller Neptune Ops Bryan Miller, President of Neptune Ops, discusses how browser companies are changing their policies regarding the use of cookies to locate specific individuals and the need for new campaign strategies to find and persuade voters online. In the post-cookie world, political consultants must consi...

Dr. Kazu Okuda, Founder, and CEO of Universal Brain, uses neurotyping based on EEG data to better understand the different types of depression and deliver more precise treatments. To facilitate the availability of EEG data, Universal Brain has developed a next-generation EEG headset that is affordable and comfortable. The headset allows for the collection of data that can be used to analyze neural profiles of patients and tailor treatments. This precision psychiatry approach is the future of depression treatment and for identifying early warning signs of depression in the younger population.

Kazu explains, "We are using the term neurotyping to solve that kind of problem. Neurotyping is a term we use at Universal Brain, and it's a groundbreaking process of grouping individuals based on brain function measures derived from the EEG data. We'll look at specific reactions of the brain to visual and audio stimuli, which are called event-related potentials, and we are leveraging that kind of brain biomarkers and neurotype the patient based on brain function."

"By examining the functioning of the cornea or systems from attention to memory and negative bias and reward function, we aim to reduce the heterogeneity of treatment groups using the brain function biomarkers because depression has a lot of phenotypes. There is no single depression, but we call it depressions because there are tons of variations of combination of the symptoms to meet the criteria of depression. So by neurotyping patients based on brain function, we reduce the heterogeneity of depressions and lead to better outcomes."


universal-brain.com

Empowered Patient Podcast: Precision Psychiatry Approach Using Neurotyping to Treat Depression with Dr. Kazu Okuda Universal Brain TRANSCRIPT Dr. Kazu Okuda, Founder, and CEO of Universal Brain, uses neurotyping based on EEG data to better understand the different types of depression and deliver more precise treatments. To facilitate the availability of EEG data, Universal Brain has developed a next-generation EEG headset that is affordab...

Dr. Kazu Okuda, Founder, and CEO of Universal Brain, uses neurotyping based on EEG data to better understand the different types of depression and deliver more precise treatments. To facilitate the availability of EEG data, Universal Brain has developed a next-generation EEG headset that is affordable and comfortable. The headset allows for the collection of data that can be used to analyze neural profiles of patients and tailor treatments. This precision psychiatry approach is the future of depression treatment and for identifying early warning signs of depression in the younger population.

Kazu explains, "We are using the term neurotyping to solve that kind of problem. Neurotyping is a term we use at Universal Brain, and it's a groundbreaking process of grouping individuals based on brain function measures derived from the EEG data. We'll look at specific reactions of the brain to visual and audio stimuli, which are called event-related potentials, and we are leveraging that kind of brain biomarkers and neurotype the patient based on brain function."

"By examining the functioning of the cornea or systems from attention to memory and negative bias and reward function, we aim to reduce the heterogeneity of treatment groups using the brain function biomarkers because depression has a lot of phenotypes. There is no single depression, but we call it depressions because there are tons of variations of combination of the symptoms to meet the criteria of depression. So by neurotyping patients based on brain function, we reduce the heterogeneity of depressions and lead to better outcomes."


universal-brain.com

Empowered Patient Podcast: Precision Psychiatry Approach Using Neurotyping to Treat Depression with Dr. Kazu Okuda Universal Brain Dr. Kazu Okuda, Founder, and CEO of Universal Brain, uses neurotyping based on EEG data to better understand the different types of depression and deliver more precise treatments. To facilitate the availability of EEG data, Universal Brain has developed a next-generation EEG headset that is affordab...

Greg Sturmer, CEO and Co-Founder, and Tom Jenkins, Chief Science Officer and Co-Founder of Elysium Therapeutics, talk about their SMART Opioid O2P, which aims to address the risks of taking opioids while still delivering the analgesic efficacy of opioids. The compound is designed to be resistant to abuse through snorting or injections and includes a trypsin inhibitor that prevents the release of the opioid when multiple pills are ingested. Elysium is also developing SOOPR, an opioid overdose rescue medication that has a longer duration of action to counteract the longer-lasting effects of synthetic opioids such as Fentanyl.

Greg explains, "When we talk about our SMART opioids for pain, SMART stands for Safer Medicines that Alleviate Risks and Trauma. Our space is led by our O2P hydrocodone product candidate, and O2P stands for oral overdose protection."

"So what O2P hydrocodone is designed to do is mitigate those major risks associated with existing prescription opioids, but doing so without sacrificing their superior analgesic efficacy, especially when compared to currently marketed non-opioid alternatives and those in development. We're excited to say that we've demonstrated human proof of concept in a recent study that we announced. But what I'd like to do is have Tom step in. Again, he is the inventor of our technology. He's a PhD synthetic organic chemist out of Stanford. Tom, do you want to talk about the technology and maybe compare it to past attempts at abuse-deterrent formulation?"

Tom elaborates, "How we answer the question and how our technology works is fairly straightforward. What we've done is we've taken the opioid molecule with hydrocodone, and we can use any opioid molecule, morphine, oxycodone, or any of the prescription opioids. What we do is make a molecular modification to the drug. The key part of that is the conditional bioavailability of the drug is the fact that the drug has to see digestive enzyme, specifically trypsin, in the small intestine before it can be converted to an active drug."


ElysiumRX.com

Empowered Patient Podcast: SMART Opioids Mitigate Risks of Opioid Abuse for Safer Pain Management with Greg Sturmer and Tom Jenkins Elysium Therapeutics TRANSCRIPT Greg Sturmer, CEO and Co-Founder, and Tom Jenkins, Chief Science Officer and Co-Founder of Elysium Therapeutics, talk about their SMART Opioid O2P, which aims to address the risks of taking opioids while still delivering the analgesic efficacy of opioids.  The compound is designed to be resista...

Greg Sturmer, CEO and Co-Founder, and Tom Jenkins, Chief Science Officer and Co-Founder of Elysium Therapeutics, talk about their SMART Opioid O2P, which aims to address the risks of taking opioids while still delivering the analgesic efficacy of opioids. The compound is designed to be resistant to abuse through snorting or injections and includes a trypsin inhibitor that prevents the release of the opioid when multiple pills are ingested. Elysium is also developing SOOPR, an opioid overdose rescue medication that has a longer duration of action to counteract the longer-lasting effects of synthetic opioids such as Fentanyl.

Greg explains, "When we talk about our SMART opioids for pain, SMART stands for Safer Medicines that Alleviate Risks and Trauma. Our space is led by our O2P hydrocodone product candidate, and O2P stands for oral overdose protection."

"So what O2P hydrocodone is designed to do is mitigate those major risks associated with existing prescription opioids, but doing so without sacrificing their superior analgesic efficacy, especially when compared to currently marketed non-opioid alternatives and those in development. We're excited to say that we've demonstrated human proof of concept in a recent study that we announced. But what I'd like to do is have Tom step in. Again, he is the inventor of our technology. He's a PhD synthetic organic chemist out of Stanford. Tom, do you want to talk about the technology and maybe compare it to past attempts at abuse-deterrent formulation?"

Tom elaborates, "How we answer the question and how our technology works is fairly straightforward. What we've done is we've taken the opioid molecule with hydrocodone, and we can use any opioid molecule, morphine, oxycodone, or any of the prescription opioids. What we do is make a molecular modification to the drug. The key part of that is the conditional bioavailability of the drug is the fact that the drug has to see digestive enzyme, specifically trypsin, in the small intestine before it can be converted to an active drug."


ElysiumRX.com

Empowered Patient Podcast: SMART Opioids Mitigate Risks of Opioid Abuse for Safer Pain Management with Greg Sturmer and Tom Jenkins Elysium Therapeutics Greg Sturmer, CEO and Co-Founder, and Tom Jenkins, Chief Science Officer and Co-Founder of Elysium Therapeutics, talk about their SMART Opioid O2P, which aims to address the risks of taking opioids while still delivering the analgesic efficacy of opioids.  The compound is designed to be resista...

Dr. Nate Favini, the first Chief Medical Officer of Pair Team, aims to connect underserved communities to high-quality, ongoing healthcare by providing medical, behavioral, and social services. Working with people who rely on Medicaid, who are experiencing homelessness and substance use disorders, and who have had recent interactions with the criminal justice system requires innovation and collaboration of government agencies, community-based organizations, and healthcare providers. With a focus on outcomes and cost, this value-based approach is reaching patients where they are, often using mobile technology and offering virtual care for tracking and improving health outcomes.

Nate explains, "In general, and specifically for the folks that we care for, value-based care means attention to the outcomes that we're delivering. For me, as a physician, that starts with the health outcomes that we deliver. So, are we improving people's health? Are we doing it on the measurable outcomes in terms of the conditions that they have, whether it's their blood sugar control for diabetes or their blood pressure if they have hypertension?"

"On the social outcomes that are drivers of people's health issues. So, are we getting you housed? Are we getting you a reliable and stable source of nutritious food? Because these are the things that make a difference in the health outcomes we're looking for."

"And then, of course, value-based care also implies attention to the cost of care. Are we delivering those outcomes at a cost that makes sense? And we've shown that we're very good at being able to achieve both of those things at the same time. At Pair Team, we have great outcomes in terms of hemoglobin A1C and blood pressure and improvements in depression. At the same time, we're offering people services that allow them to go to the emergency department and be in the hospital last. And so the real sweet spot in value-based care is if you can improve the outcomes for the folks who need it and return those investments to the system in the shape of lower spending."


pairteam.com

Empowered Patient Podcast: Connecting Vulnerable Populations to High-Quality Healthcare Services Using Mobile Access and Community-Based Partners with Dr. Nate Favini Pair Team TRANSCRIPT Dr. Nate Favini, the first Chief Medical Officer of Pair Team, aims to connect underserved communities to high-quality, ongoing healthcare by providing medical, behavioral, and social services. Working with people who rely on Medicaid, who are experiencing homelessness and substance use disorders, a...

Dr. Nate Favini, the first Chief Medical Officer of Pair Team, aims to connect underserved communities to high-quality, ongoing healthcare by providing medical, behavioral, and social services. Working with people who rely on Medicaid, who are experiencing homelessness and substance use disorders, and who have had recent interactions with the criminal justice system requires innovation and collaboration of government agencies, community-based organizations, and healthcare providers. With a focus on outcomes and cost, this value-based approach is reaching patients where they are, often using mobile technology and offering virtual care for tracking and improving health outcomes.

Nate explains, "In general, and specifically for the folks that we care for, value-based care means attention to the outcomes that we're delivering. For me, as a physician, that starts with the health outcomes that we deliver. So, are we improving people's health? Are we doing it on the measurable outcomes in terms of the conditions that they have, whether it's their blood sugar control for diabetes or their blood pressure if they have hypertension?"

"On the social outcomes that are drivers of people's health issues. So, are we getting you housed? Are we getting you a reliable and stable source of nutritious food? Because these are the things that make a difference in the health outcomes we're looking for."

"And then, of course, value-based care also implies attention to the cost of care. Are we delivering those outcomes at a cost that makes sense? And we've shown that we're very good at being able to achieve both of those things at the same time. At Pair Team, we have great outcomes in terms of hemoglobin A1C and blood pressure and improvements in depression. At the same time, we're offering people services that allow them to go to the emergency department and be in the hospital last. And so the real sweet spot in value-based care is if you can improve the outcomes for the folks who need it and return those investments to the system in the shape of lower spending."


pairteam.com

Empowered Patient Podcast: Connecting Vulnerable Populations to High-Quality Healthcare Services Using Mobile Access and Community-Based Partners with Dr. Nate Favini Pair Team Dr. Nate Favini, the first Chief Medical Officer of Pair Team, aims to connect underserved communities to high-quality, ongoing healthcare by providing medical, behavioral, and social services. Working with people who rely on Medicaid, who are experiencing homelessness and substance use disorders, a...