Indicar - Interdisciplinary Cancer Research

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Our fellow Alessio Terenzi has published as co-author in Scientific Reports: “Biological activity of PtIV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis”.
The new study is a joint effort between the group of Prof. Luca Salassa (Donostia International Physics Center) and the groups of Profs. Walter Berger and Bernhard K. Keppler (Research Platform “Translational Cancer Therapy Research”, University of Vienna and Medical University of Vienna). The study highlights the possibility of combining photocatalysis and Pt(IV) prodrugs in the treatment of cancer. Congratulations!!

Biological activity of PtIV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis Article

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Our fellow Nicola Silva has published as co-author in PLOS Genetics: “C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata”. Congratulations Nicola!

C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata Author summary The creation of a viable individual from the fusion of egg and s***m requires that they each contain the correct number of chromosomes. This is ensured through the meiotic divisions, which initially fasten identical chromosomes together through DNA linkages that hold them together unt...

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The INDICAR-Fellow Nicola Silva has published as corresponding author in PLOS Genetics: “BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis”. Congratulations Nicola!!

BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis Author summary Sexually reproducing species rely on meiosis to transmit their genetic information across generations. Parental chromosomes (homologues) undergo many distinctive processes in their complex journey from attachment to segregation. The physiological induction of DNA double strand breaks....

The INDICAR-Workshop 2018 took place in Bratislava (Slovakia), from 13th to 14th Sep. The INDICAR Workshop is the opportunity for post-doctoral researchers enrolled in the INDICAR Program to discuss common themes and exchange cross-disciplinary results with a particular focus on the techniques used to reach their goals. As the INDICAR Programme ends November 2018, the fellows presented and discussed their work with a particular focus on how to wrap up outcomes and what the results may mean for future research.

Our fellow Antje Koller took part in an educational video discussing the latest advances on breakthrough cancer pain (BTcP). The video is aired on ecancer tv, an organization devoted to provide educational content free to the global oncology community.

Dr Koller discusses together with the host, Dr Andrew Davies, and the rest of the panel members, Dr Didier Mayeur and Dr Jason Boland, the latest perspectives on BTcP, its impact on patients’ lives, the current strategies and the importance of individualized treatments and multi-disciplinary approaches.

Please notice that watching the video requires previous registration on ecancer.org.

The latest understanding of breakthrough cancer pain management. The latest understanding of breakthrough cancer pain management. Oncology videos for healthcare professionals - ecancer Dr Andrew Davies is joined by Dr Didier Mayeur, Dr Antje Koller and Dr Jason Boland, to discuss the latest perspectives on breakthrough cancer pain (BTcP). The discussion starts around the definition of BTcP and whether it is a well-recognised concept within oncology. Citing current research, it is....

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The INDICAR Fellow Laura Cimatti published as last author in the Journal RNA Biology: “Organ-wide profiling in mouse reveals high editing levels of Filamin B mRNA in the musculoskeletal system”. Congratulations Laura! 💪👍

www.tandfonline.com

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Our fellow Luca Tubiana just published as corresponding author in the European Physical Journal E Soft Matter: “Implementing efficient concerted rotations using Mathematica and C code⋆”. Congratulations, Luca! 👍👏👏

https://link.springer.com/article/10.1140/epje/i2018-11694-7

Implementing efficient concerted rotations using Mathematica and C code⋆

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The INDICAR-Fellow Luca Tubiana has published as corresponding author in the European Physical Journal E Soft Matter: “KymoKnot: A web server and software package to identify and locate knots in trajectories of linear or circular polymers”, and his research article has been featured on the cover! Congratulations Luca!!🎉👏👏

KymoKnot: A web server and software package to identify and locate knots in trajectories of linear or circular polymers Abstract. The KymoKnot software package and web server identifies and locates physical knots or proper knots in a series of polymer conformations. It is mainly intended as an analysis tool for...

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Our fellow Alessio Terenzi has published as co-author in the European Journal of Medicinal Chemistry: “Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction”. Congratulations!!👍👏
https://www.sciencedirect.com/science/article/pii/S0223523418305476

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The INDICAR-Fellow Alessio Terenzi co-authored a publication in the European Journal of Inorganic Chemistry: “Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis‐1,8‐naphthalimide Ligands”. Congratulations Alessio! 👏👏
https://onlinelibrary.wiley.com/doi/10.1002/ejic.201800384

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The INDICAR-Fellow Nicola Silva co-authored a PLoS Genetics publication: “The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans”. Congratulations Nicola!
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007453

On the 7th of June the INDICAR Fellow Konstantinos Kiakos presented his video “Drugging Cancer” at Top Kino, together with participants of the CommunicationHub.
Last October Konstantinos enrolled the CommunicationHub 2017/18 programme “My research as video“, organized by Wissenstransfer. Konstantinos worked on his video under the guidance and support of experts from Okto.
“Drugging Cancer” aims at disseminating the INDICAR program and Konstantinos’ research and to raise awareness on the research performed to discover new cancer drugs.

Drugging Cancer CommunicationHub 2017/2018 - My research as video “Cancer is the second leading cause of mortality worldwide. Approximately 1 in 3 people will develop some f...