We use zebrafish primordial germ cells to study:
- Cell fate specification and maintenance
- Cell motility
- Directed cell migration
In contrast with other organisms, the PGCs of zebrafish originate at random positions with respect to the dorsoventral axis. Yet, within 24 hours of development most of the cells arrive at distinct bilateral positions from which they coalesce into a gonad. We use zebrafish PGCs as model for cell fate specification, motility and directed migration in vivo 3D environment. Different research lines in
18/10/2019
Das Daumendrücken hat geholfen: Ines Sandbote, technische Assistentin bei uns am UKM, und ihr Partner Olaf Dirker, Gesundheits- und Krankenpfleger am UKM Marienhospital Steinfurt, haben am vergangenen Samstag den auf Hawaii erfolgreich gefinished. "Eine unglaubliche Erfahrung - und eine sehr anstregende dazu", so das Fazit von Sandbote nach dem Rennen. Wir sind stolz auf euch und gratulieren zu dieser Wahnsinnsleistung!!! 👏💪 🏊🚴🏃
15/10/2019
15/10/2019
Proudly we would like to congratulate our colleague Ines for achieving the qualification for the Ironman Hawaii making her biggest dream becoming true...
We praise her determination and hard work to accomplish something very few people are capable of.
We hope she could enjoy this special experience and we are looking forward to hearing her stories when she is back next week :)
26/07/2019
11/06/2018
Letzte Woche haben wir ein neues Gruppenbild für unsere homepage gemacht: https://www.medizin.uni-muenster.de/fileadmin/_processed_/9/f/csm_Razlab_2018_9a47b0f8b0.jpg
Last week we updated our group picture on our webpage: https://www.medizin.uni-muenster.de/fileadmin/_processed_/9/f/csm_Razlab_2018_9a47b0f8b0.jpg
11/06/2018
Ebenfalls gratulieren wir herzlichst Divyanshu Malhotra zur erfolgreich verteidigten Doktorarbeit am 28. Mai 2018.
Wir wünschen ihr alles erdenklich Gute und viel Erfolg für ihre Zukunft!
Congratulations to our colleague Divyanshu Malhotra, who successfully defended her PhD on 28th of May. We wish her all the best for her future!
11/06/2018
Herzliche Glückwünsche vom gesamten Labor gehen an Theresa Groß-Thebing, die am 11.April 2018 erfolgreich ihre Doktorarbeit verteidigt hat. Wir wünschen ihr alles erdenklich Gute und viel Erfolg für die Zukunft!
Congratulations to our colleague Theresa Groß-Thebing, who successfully defended on the 11th of April her PhD thesis. We wish you all the best and success for her future!
10/04/2018
Recently another article from our lab about the function of Hsp90aa1.2 during PGC migration was published in Developmental Biology. Have a look!
Rapid progression through the cell cycle ensures efficient migration of primordial germ cells – The role of Hsp90 Zebrafish primordial germ cells (PGCs) constitute a useful in vivo model to study cell migration and to elucidate the role of specific proteins in thi…
At the end of last year another work from our lab was published in Developmental Cell. This study is about the fate maintenance of the PGCs when lacking the dead end protein. Here you can read more about it:
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30954-1
The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation Primordial germ cells (PGCs) maintain their fate during their migration within the embryo. Through monitoring PGCs in live zebrafish embryos, Gross-Thebing et al. uncover a key role for the vertebrate-specific RNA-binding protein Dead end (Dnd) in protecting and maintaining germ cell fate. Dnd-defi....
At the end of November our lab published an article in Developmental cell on the Membrane of the PGCs. Have a look at it!
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30874-2
Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations Blebs are cellular protrusions that play key roles in a range of physiological and disease processes. Employing the primordial germ cells of zebrafish as an in vivo model for cell migration, Goudarzi et al. show that the rapid expansion of protrusions of this type depends on unfolding of membrane .....
16/01/2018
Wir gratulieren ganz herzlich unseren jüngsten Absolventen Florian Hörner, Mohammad Goudarzi und Jana Pfeiffer zur erfolgreichen Verteidigung.
Recently, Florian Hörner, Mohammad Goudarzi and Jana Pfeiffer successfully defended. Congratulations to all of you!
27/06/2017
Maria Sharkova und Isabel Schumacher arbeiten im Rahmen des MedK Programmes in unserem Institut an Ihren Promotionen und werden unser Team in den kommenden 6 Monaten verstärken.
Herzlich Willkommen!
The medical students Maria Sharkova und Isabel Schumacher joined our lab to work on their PhD in the context of the MedK program and are going support our team during the coming 6 month.
Welcome!