10/13/2026
"The insect female reproductive tract includes the uterus, oviduct, s***m storage organs, and glands, which are essential for fertility but understudied."
So began evolutionary and developmental geneticist Rachel Thayer in her research paper, "Regional Specialization, Polyploidy, and Seminal Fluid Transcripts in the Drosophila Female Reproductive Tract," published in the Oct. 25, 2024 issue of the Proceedings of the National Academy of Sciences (PNAS).
Rachel Thayer, now a postdoctoral fellow in the lab of UC Davis Distinguished Professor David Begun, Department of Evolution and Ecology, will speak on "Evolutionary Genomics of the Drosophila S***m Storage System" at the UC Davis Department of Entomology and Nematology seminar, set or 12:10 p.m., Wednesday, Oct. 14 in 122 Briggs Hall.
Her presentation also will be on Zoom. The Zoom link: https://ucdavis.zoom.us/j/95882849672
"S*xual selection drives extreme traits and coevolution, especially in reproductive tissues," Thayer writes in her abstract. "Seminal fluid proteins in Drosophila are an iconic case study for post-copulatory s*xual selection. A leading explanation for these s*xually transferred proteins’ rapid adaptation is their potential to manipulate female physiology to advance male fitness, generating long-term s*xual conflict. However, this co-evolutionary model requires counter-evolution in females, which we sought to find by characterizing gene expression evolution in the female tissues that contact seminal fluid (i.e. the uterus, s***m storage organs, female glands). Instead, we found surprises that challenge the prevailing model and highlight the necessity of greater nuance and female inclusion to understand both physiology and molecular evolution."
"First, we found that females themselves express more than 45 percent of the genes previously believed to encode male-limited seminal fluid proteins, primarily inside their s***m storage organs," she noted. "This result immediately complicates the idea that manipulating females is the salient function of SFPs, suggesting instead that females use these proteins in secreted fluids that support s***matozoa, and that selection on these genes may also occur in females. Next, I share progress on re-evaluating the molecular evolution of these proteins by incorporating female variation across the levels of protein sequence, inter-population differences, and macroevolutionary contrasts. Because female s***m storage is pervasive in insects, these co-evolutionary dynamics may be broadly representative."
Thayer is currently studying "functional evolution in the insect female reproductive tract as a National Institutes of Heatlh K99 Pathway to Independence Research Scholar at UC Davis," mentored by David Begun.
https://ucanr.edu/blog/bug-squad/article/targeting-reproductive-system-female-fruit-fly