10/20/2026
More treatment options matter.
The FDA has approved IDVYNSO, a complete, once daily, two drug HIV treatment combining Doravirine and Islatravir in a single tablet.
What makes this approval especially noteworthy?
• No Tenofovir
• No Integrase Inhibitor
• One tablet taken once daily
• A complete two drug regimen
IDVYNSO is approved as a switch option for certain adults who are already virally suppressed on a stable treatment regimen, have no history of virologic treatment failure, and have no known resistance substitutions associated with Doravirine.
This is significant because HIV treatment is not one size fits all. As people living with HIV live longer and manage other health conditions, having additional treatment options can support more individualized conversations about long term care, tolerability, medication interactions, and overall health.
IDVYNSO will not be appropriate for everyone. Resistance history, Hepatitis B status, other medications, and potential drug interactions must be carefully reviewed with an HIV care provider. This information is being shared for educational purposes and is not a recommendation to change treatment.
Progress in HIV care is not only about developing new medications. It is also about expanding informed choices for people living with HIV.
https://www.merck.com/news/fda-approves-mercks-once-daily-idvynso-doravirine-islatravir/
IDVYNSO is approved for adults with virologically suppressed HIV-1 with no history of virologic treatment failure and no known substitutions associated with resistance to doravirine IDVYNSO is the first and only non-INSTI, tenofovir-free, once-daily, complete two-drug regimen to demonstrate non-infe...