The American Society for Cell Biology

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The American Society for Cell Biology ASCB is an inclusive, international community of biologists studying the cell, the fundamental unit of life.
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10/14/2026

From MBoC: How do cells keep their internal scaffolding organized?

Researchers studying Drosophila epithelial cells found that the continuous turnover of actin filaments plays an important role in organizing another part of the cell’s cytoskeleton: microtubules.

When the actin regulator CAP was disrupted, actin accumulated at the cell surface, pushing microtubules out of position and interfering with processes including intracellular trafficking and microvilli formation.

Read “Apical actin filament turnover mediated by cyclase-associated protein coordinates non-centrosomal microtubules in epithelium”:
https://www.molbiolcell.org/doi/10.1091/mbc.E26-07-0321

nnovation in the classroom drives discovery beyond it.Congratulations to Kristen Johnson of the University of New Hampsh...
10/13/2026

nnovation in the classroom drives discovery beyond it.

Congratulations to Kristen Johnson of the University of New Hampshire, recipient of the 2026 ASCB Innovation in Education Award.

The award recognizes educators whose creative approaches have made a significant impact on advancing science education and ASCB's mission.

ASCB is proud to celebrate Dr. Johnson's achievements.

Learn more:
https://www.ascb.org/society-news/ascb-announces-2026-honorific-award-winners/

10/12/2026

From MBoC: What brings individual mRNAs together to form clusters inside a cell?

Using Drosophila embryos, researchers found that clustering of oskar mRNA is driven by a combination of RNA concentration, the RNA-binding protein Staufen, and an RNA palindrome that allows mRNAs to pair with one another.

The team also identified other mRNAs that may contain similar palindromes, raising the possibility that this type of RNA-RNA interaction could be a broader mechanism for organizing mRNAs within cells.

Read “In vivo clustering of oskar mRNA is driven by RNA concentration, RNA binding proteins, and an RNA palindrome”:
https://www.molbiolcell.org/doi/10.1091/mbc.E26-04-0176

10/09/2026

From MBoC: A better way to watch an elusive signaling lipid in action.

PI(3,5)P₂ plays an important role in endosomal function, but its low abundance has made it difficult to track in living cells.

In “Quantitative comparison of PI(3,5)P2 biosensors reveals SnxA is the most sensitive and unbiased,” researchers systematically compared available biosensors and found that SnxA provides a sensitive and reliable way to monitor PI(3,5)P₂ dynamics in real time—opening new possibilities for studying its role in normal cell function and disease.

Read the research:
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0120

Today's early-career innovators are tomorrow's scientific leaders.ASCB congratulates Jiefu Li of Janelia HHMI, recipient...
10/06/2026

Today's early-career innovators are tomorrow's scientific leaders.

ASCB congratulates Jiefu Li of Janelia HHMI, recipient of the 2026 Günter Blobel Early Career Award.

The award recognizes outstanding independent investigators whose innovative research is advancing the field of cell biology early in their careers.

Congratulations, Dr. Li!

Learn more:
https://www.ascb.org/society-news/ascb-announces-2026-honorific-award-winners/

See how artificial intelligence and high-throughput sequencing are being combined to advance antibody discovery.In this ...
10/06/2026

See how artificial intelligence and high-throughput sequencing are being combined to advance antibody discovery.

In this free November 17 webinar, Perry Wasdin, PhD, will discuss MAGE, a protein language model capable of generating novel and diverse antibody sequences with experimentally validated binding specificity. Proof-of-concept work includes antibodies targeting SARS-CoV-2, RSV-A, and H5N1.

Learn more and register:
https://www.ascb.org/ascb-meetings/generation-of-antigen-specific-paired-chain-anitibodies-using-large-language-models/

10/05/2026

From MBoC: How could a cellular cleanup process contribute to the spread of a protein linked to Parkinson’s disease?

Researchers found that RTN3L-dependent ER-phagy, a pathway cells use for protein quality control, helps move α-synuclein through endolysosomal compartments and ultimately contributes to its secretion.

The findings suggest that α-synuclein release may arise as a by-product of a normal cellular clearance mechanism—providing new insight into how intracellular protein quality control could contribute to the spread of neurodegenerative pathology.

Read “Clearance and secretion of α-synuclein by RTN3L-mediated endoplasmic reticulum autophagy”:
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138

10/02/2026

From MBoC: What has to change inside a cell to transform a fertilized egg into an embryo ready for its first division?

In the Perspective “Setting up for embryogenesis: subcellular changes at the meiosis to mitosis transition,” Helena Cantwell explores the rapid cellular remodeling that takes place as an egg transitions from meiosis to the first mitotic division.

The article examines changes to the spindle, centrosomes, and chromosomes—and the molecular and biophysical mechanisms that coordinate this critical transition in early development.

Read the Perspective:
https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0484

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